Objective 1

Inclusion of proteins of the pulmonary surfactant to nano-objects

The pulmonary surfactant system is a lipid-protein complex, synthesized and secreted into the lung airspaces, whose main function is to stabilize the large respiratory surface against physical forces tending to collapse. To do so, surfactant forms surface active films able to reduce dramatically the surface tension at the respiratory air-liquid interface. In this context, hydrophobic surfactant proteins SP-B and SP-C play a crucial role to promote rapid and efficient transfer of the surface active lipids into the interface. In NANOBIOSOMA, SP-B and SP-C molecules, or some of their fragments, will be incorporated into different nanoobjects (liposomes, nanocapsides, nanodiscs), to facilitate their proper integration into different surfaces, and particularly, to produce efficient drug vehiculization entities directed to the lung.